CELLULAR SIGNALING WITH NITRIC OXIDE (NO) Nitric Oxide (NO) is synthesized endogenously and plays a central role in cell-to-cell signaling. NO is synthesized from L-arginine by the action of nitric oxide synthases (NOS) in a two-step oxidation process, with a half-life of a mere 5 seconds. NO has the ability to cross cellular membranes under a very fast diffusion rate, and functions as one of the most primary components of human health. The main issue related to the utilization of NO donors in humans is based on the fact that most investigators could not envision how a molecule as toxic as NO could function in a biological setting. NO functions as both a toxic and non-toxic agent, depending on its biosynthesis.

NO acts as a highly reactive, diffusible, and unstable radical under certain circumstances. Thus, researchers have sought stable NO donors with potential therapeutic value. A stable NO donor must be capable of controlling the amount and rate of NO release in the human body in order to avoid potential toxic side-effects. The by-products of a programmed NO-reaction must possess minimal side-effects, or it cannot be used without danger of negative reactions. The NO-delivery-dose must be sufficient to induce health benefits without triggering negative physiological effects. This elemental dose ranges from 3 grams to 20 grams per day of a NO-donor. Said doses are appropriate in cases of impotence and fertility. A targeted-release of NO by a NO-donor requires a Low Glycemic delivery system that contains a Blind Amino Acid® Rider (BAAR). The most stable non-drug NO-donor is FF L-Arginine bound to a BAAR, which is the substrate for nitric oxide synthase. This form of L-Arginine reverses the inhibition of nitric oxide synthase caused by arginine analogs, and is proven safe in humans long-term in doses of 3g - 20g daily.

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